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Inhibition of either system leads to increased levels of -synuclein, and some evidence suggests that there is compensatory crosstalk between the two systems

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Therefore, it is tempting to speculate that a similar situation might occur in the case of native GPx3, which would show the highest activity in tetrameric form

Gila-Daz A, Herranz Carrillo G, Caas S

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43,44 Filament formation can confer numerous allosteric effects and is spatially and temporally resolved in the cell