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Mechanistic Research Perspective Disruption of FOXO4p53 protein interaction Activation of p53-mediated apoptosis pathways Modeling senescent cell survival and removal mechanisms Analysis of transcription-factor signaling networks Investigation of age-related cellular stress responses Primary Research Applications Cellular Senescence Studies: FOXO4-DRI is widely used in experimental models to investigate how senescent cells accumulate and influence tissue function
To date, a number of senotherapeutics have progressed into clinical phase and tested in those with age-related disorders
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J Endocrinol Invest 18: 134139 [DOI] [PubMed] [Google Scholar] Di Renzo M.F., Poulsom R., Olivero M., Comoglio P.M., Lemoine N.R
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