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Here we report the crystal structures of the regulatory sulphenic and irreversible sulphinic and sulphonic acids of protein tyrosine phosphatase 1B (PTP1B), an important enzyme in the negative regulation of the insulin receptor 7,8 and a therapeutic target in type II diabetes and obesity 9

This notion is consistent with the aberrant GSH and GSSG content detected in the brain of Tst / mice, where GSH was 36 % lower in Tst / mice, and its oxidized form, GSSG, increased five times

Evidence signal Longevity research 7 source-backed citations are connected to this page

10.1136/gpsych-2023-101143 115 XuY.YeX.DuY.YangW.TongF.LiW.et al (2025)

doi: 10.1038/ijo.2010.227 97 NalivaevaNNZhuravinIATurnerAJ
