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Investigators have also noted that the pronounced appetite-stimulating effect of MK-677 an on-target consequence of ghrelin receptor agonism in hypothalamic appetite circuits complicates body composition endpoints in metabolic studies, as caloric intake must be carefully controlled to isolate GH-axis-mediated changes from orexigenic-driven weight gain

doi: 10.1007/s10815-015-0584-1

To date, no standardized experimental model has been established that would allow simultaneous assessment of both wound-healing and analgesic efficacy of peptides at the level of injured skin

F., Hayes, K

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