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Nocturnal protein intake raises insulin levels late, generating a curve that declines slowly

KARs especially those containing Glutamate receptor ionotropic kainate 4 and 5 (GluK4/GluK5), mediate oligodendrocyte and neuronal vulnerability (Lerma and Marques, 2013)

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Dietary intake has recently been shown to modulate the breath metabolome 59 , however we had insufficient nutritional data to adjust for this potential confounder

6.4.5 Neuroprotective agents Pharmacological agents that promote neuronal survival and protect against neuroinflammation, such as antioxidants or specific enzyme inhibitors (e.g., COX-2 inhibitors), may also hold therapeutic potential (Liu et al., 2023)

The main residues involved in these modifications are the most reactive cysteines in GSTP1-1, namely, Cys47, and/or Cys101