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Balancing between cuproplasia and copper-dependent cell death: molecular basis and clinical implications of ATOX1 in cancer

Additionally, melatonin significantly attenuated the fibrosis process by suppressing the activation of TGF-1/SMAD signaling in heart (Yeung et al., 2015), which resulted in the reduction of collagen deposition in the heart tissues

The major biological factors that drive the observed sex differences in AD include differences in age-related sex hormone reduction, the incidence of genetic risks (ApoE, etc.), the impact from risks of other diseases (diabetes, depression, cardiovascular disease), and the age-related declines in brain volume and brain glucose metabolism (247, 252, 258, 263)