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When cells become acutely stressed, one of the main responses is the formation of stress granules

(14) The third system operates in the peroxisomes of liver cells through catalase activity that metabolizes alcohol to acetaldehyde through peroxidation in the presence of hydrogen peroxide (H2O2) which is then transformed into water

Resveratrol improves circulating lipids and renal dysfunction, reduces lipid deposition in the kidney by modulating the junctional adhesion molecule-like protein/Sirt1 lipid synthesis pathway, and ameliorates DKD (220)

Its copper-mediated activity is linked to collagen synthesis, angiogenesis, and cellular signaling in models of injury and aging

Based on these findings, 200 g/mL Se/LDH@PEG-M was selected for subsequent in vitro cell experiments