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They disrupt fundamental cellular processes, including energy production, insulin signaling, glucose metabolism, and mitochondrial function, at times contributing to cognitive decline, fatigue, reduced ability to fight infections, and increased chronic disease risk

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This means that it cannot be naturally synthesized in your body

The ob/ob and db/db mice exhibited an increase in intestinal permeability and significantly higher plasma endotoxin and proinflammatory cytokines such as IL-1 , IL-6, INF , and TNF- compared to wild-type mice

GLP-1 also decreases hepatic glucose production by inhibiting glucagon secretion from cells, and increases insulin sensitivity in skeletal muscle through an indirect mechanism by increasing microvascular recruitment in skeletal muscle which may potentiate local insulin action