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This multidisciplinary model, together with machine learning approaches to better mine the data, should provide new insight into the microbial-gut barrier nexus for improved personalized CRC prevention and disease treatment strategies

Pro-inflammatory mediators, such as TNF- and IL-1, enhance iron dysregulation by promoting ferritin degradation and releasing free iron into the cytosol

(7) Chronic inflammation is closely linked to oxidative stress and plays a significant role in the progression of these diseases, worsening symptoms and contributing to ongoing tissue damage

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Techniques such as atomic force microscopy (AFM) and optical tweezers allow researchers to measure the mechanical properties of collagen fibers and other extracellular matrix components with high precision