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Authors' Contributions Liu JR, Deng ZH, Zhu XJ, Zeng YR, Guan XX, and Li JH contributed to this paper

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By inhibiting NNMT, the compound prevents the depletion of both NAD+ and SAM in adipocytes, two factors that are critical for maintaining metabolic flexibility

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5-Amino-1MQ is studied for its relationship to NNMT pathway activity, a pathway of interest in metabolic research models involving adipocyte biology, NAD+-adjacent metabolism, methylation-related signaling, and cellular energy regulation