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Description
This histone octamer forms the core of a nucleosome around which the DNA is wrapped

One of its unique features is how it builds up in tissues that face the greatest oxidative stress, including the liver, kidneys, and skin

Nature 414:821821 Adib M, Peytam F, Rahmanian-Jazi M, Mahernia S, Bijanzadeh HR, Jahani M, Mohammadi-Khanaposhtani M, Imanparast S, Faramarzi MA, Mahdavi M (2018) New 6-amino-pyrido [2,3-d] pyrimidine-2,4-diones as novel agents to treat type 2 diabetes: a simple and efficient synthesis, alpha-glucosidase inhibition, molecular modeling and kinetic study

Cisplatin is an anticancer drug that has shown clinical efficacy against a variety of cancers

PubMed, Zhang, Yu, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Landis C.A., Lentz M.J., Rothermel J., Buchwald D., Shaver J.L
