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Other than exogenous products, lifestyle interventions (such as diet modification and exercise prescription) are also biologically plausible to act as adjunctive therapies and should be further explored in preclinical models, particularly due to bias derived from behavioral modification in such clinical trials [59] (Figure 2)

A growing literature shows that methamphetamine alters peripheral and central immune functions and that immune factors such as cytokines, chemokines, and adhesion molecules play a role in the development and persistence of methamphetamine induced neuronal injury and neuropsychiatric impairments

While these conversations have fueled demand, many of the claims circulating online remain largely unproven in human studies

Chen H, Zhang Y, Miao Y, Song H, Tang L, Liu W, et al

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