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This technology has the potential to enhance imaging techniques and the delivery of therapeutic agents through effective vectorization to the biological site and optimization of pharmacokinetics and pharmacodynamics, with the aim of reducing toxicity, improving drug stability and solubility [10,12,18,19]

For example, the deletion of p53 prevents the nuclear accumulation of dipeptidyl peptidase-4 (DPP4), thus facilitates plasma-membrane-associated DPP4-dependent lipid peroxidation, which finally results in ferroptosis

Dissolution of this complex restores the sensitivity of hepatocellular carcinoma cells to erastin

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Pandi Peng and Weixia Li for their invaluable assistance in the flow cytometry experiment
