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Use single-use needles and syringes only never share equipment between individuals

The SURPASS program included five major trials, and metformin was a permitted or required background medication in most of them

They point out that Zepbound is the only GLP-1 therapy approved for obesity with sleep apnea, that some patients tolerate one drug but not the other, and that studies suggest Zepbound may deliver greater weight loss than Wegovy

In March 2025, the FDA ended enforcement discretion for compounded tirzepatide after determining that no drug shortage exists

Due to its toxicity, the EPA has restricted the use of Paraquat and it is currently banned in over 30 countries

Clinical trial data covering up to 72 weeks shows a favorable safety profile in most patients, with the most common side effects being GI-related and typically resolving during dose escalation