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Downregulation of ATP5A1, the ATP Synthase F1 Subunit Alpha [123], and ATP5G3, the ATP synthase F0 complex subunit C3 [124], was observed in the postmortem study of ASD patients in all examined regions [122], which could inhibit the activity of complex V [79] and promote the ETC breakdown due to opening of the mPTP [125, 126]

Supplementation with acetyl-L-carnitine (100-300 mg/kg) for several weeks restores these parameters toward youthful levels

The other authors declare no conflict of interests

Future prospective studies should use more extensive fatigue questionnaires, such as the Fatigue Assessment Scale (FAS) (64) or the 11-point fatigue numeric rating scale (NRS) (65, 66)

& Shirazi, A

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