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Description
J.et al (1971)

In laboratory settings, GHK-Cu is widely studied for its role in modulating gene expression related to collagen synthesis, matrix remodeling, and antioxidant defense pathways

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The use of naloxone allowed the researchers to confirm that the observed antinociceptive effects were mediated through opioid receptor activation

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They also ran flow cytometry (Annexin V/PI staining) and western blot analysis to measure specific survival and death markers: Bcl-2, Bax, caspase-3, and PARP
