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Research from the University of Copenhagen's circadian metabolism lab found that amylin's satiety effect was 22% stronger when administered in the late afternoon (4-6pm) compared to early morning (6-8am), independent of meal timing

Gut hormone co-agonists for the treatment of obesity: from bench to bedside

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In addition, as we age, our ability to absorb B12 from food declines, which puts the elderly at higher risk of deficiency

doi: 10.1016/j.freeradbiomed.2007.10.054