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Third, it increases levels of leu-enkephalin, a natural opioid peptide involved in pain relief and mood elevation
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Starting the peptide around the 15-20 pound loss mark allows time for collagen remodeling to keep pace with volume reduction

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Dimet-Wiley/Neelakantan (muscle aging, 24-month-old mice, NNMTi 510 mg/kg): increased muscle stem cell proliferation and fusion, ~2-fold greater fiber cross-sectional area, and roughly +70% peak tibialis anterior torque versus controls
