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This concept of cancer hallmarks has become an enduring theme in cancer research

These microsomal membrane-bound, heme-thiolate proteins, located mainly in the liver, but also in enterocytes, kidneys, lung, and even the brain, are responsible for the oxidation, peroxidation, and reduction of several endogenous and exogenous substrates [13, 15, 16]

J Pharm Res 11(12):15131517 Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview

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This review also highlighted shared resistance mechanisms across treatment modalities and discussed emerging strategies to overcome these barriers