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Because there is no promising diseasemodifying medication for DPN, the pain itself needs to be managed when treating painful DPN

Therefore, more research is necessary to validate findings from preliminary and small scale studies
Jianshang Huang and Yunsheng Dong and Jingjing Ji agreed to be accountable for all aspects of the work, ensuring that any issues related to the accuracy or integrity of any part of the work are appropriately investigated and resolved The authors have declared that no competing interest exists
Insulin/IGF-1 paradox of the aging process Currently, it is known that several signaling networks co-operate in the regulation of the aging process

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