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These can also trigger a rare allergic reaction called anaphylaxis

Spray format is used in research applications where a pre-mixed solution is preferred

Gastroenterology 125 , 10321041 (2003)

Certain patients naturally resist ICIs, while others show a significant reduction in treatment effectiveness or fail to respond after a set treatment period [117]

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Lai X, Wu X, Hou N, Liu S, Li Q, Yang T, et al