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At the individual level, several previous studies have shown that mental disorders have the potential to contribute to a range of other problems, including an increased suicide risk as well as reduced quality of life across multiple domains, including impairments in physical and social functioning (16)

Suberoylanilide hydroxamic acid (SAHA), another HDACi, produced similar results to NaBu, demonstrating transcriptional activation is not HDACi specific [80-82]