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The chemical structure is: Dihydroergotamine mesylate nasal spray is provided for intranasal administration as a clear, colorless to light yellow aqueous solution in an amber glass vial containing: Each milliliter contains (equivalent to 3.43 mg dihydroergotamine) Mechanism of Action Dihydroergotamine binds with high affinity to 5-HT1D and 5-HT1D receptors