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What the published research reported A phase-2 randomized trial published in the New England Journal of Medicine in 2023 studied retatrutide in adults with obesity and reported substantial, dose-dependent reductions in body weight over 48 weeks, alongside a gastrointestinal side-effect profile broadly similar to other incretin drugs

If your B12 levels are already solid, the impact might be minimal

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Putting the Numbers in Context The beta coefficients from this meta-analysis represent the independent effect of each treatment after controlling for confounding variables

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Again, the safest bets are using them at different times of day (Vitamin C in AM, CP in PM is popular) or using more stable Vitamin C derivatives