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If such a vicious cycle of glutamate excitotoxicity, oxidative stress, and mitochondrial dysfunction does indeed underpin ME/CFS pathology, it may not be clear where exactly the root problem lies

doi: 10.1155/2021/2915019 64 MaoCLiuXZhangYLeiGYanYLeeHet al

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Alzheimers disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein

A review of randomized controlled trials published in the PubMed, EMBASE, Web of Science and Cochrane Library databases concluded that folate supplementation had no effect on blood pressure and lipids in patients with metabolic diseases (95)