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Chiecho and colleagues showed that acetyl-L-carnitine in rats altered the DNA in the spinal cord cells by increasing the production of mGlu2 receptors, an important receptor for pain relief [3]

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The model is also consistent with published results that show that female mice are less susceptible than males to hepatotoxicity due to acetaminophen overdose and suggests that this might also be true for humans, though the human epidemiological data are contradictory.

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