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The majority of lead and cadmium contaminations is relatively low-level, within the parts per billion range (0.1100 g L 1 ), and is no longer considered an acute heavy metal poisoning

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According to the dopamine-acetylcholine balance hypothesis, dopamine depletion leads to severe deterioration of basal ganglia circuit dynamics, resulting in overactivation of the cholinergic system and subsequent motor and cognitive impairments

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