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After the lesion and inflammation disappear, a dark spot forms on the skin, corresponding almost exactly to the shape of the lesion

In doxorubicin-resistant liver cancer (BEL-7402/ADM) cells, apigenin restores drug sensitivity by reducing nuclear factor erythroid 2-related factor 2 (NRF2) expression at both RNA and protein levels through PI3K/AKT pathway inhibition, thereby increasing intracellular doxorubicin [58, 59]

On the other hand, mitochondrial Ca 2 + efflux occurs via the Na + /Ca 2 + /Li + exchanger (NCLX) and Ca 2 + /H + exchanger (LETM1) on the inner membrane (Calvo-Rodriguez and Bacskai, 2021

Author contributions FW: Validation, Conceptualization, Software, Writing original draft, Formal analysis, Methodology, Data curation, Visualization

In adults, excessive growth hormone for a long period of time produces a condition known as acromegaly in which patients have excessive growth of the hands and feet and altered facial features