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Moreover, FUS was found to directly bind to G 4 C 2 repeat RNA and modify its G-quadruplex structure as an RNA chaperone, resulting in the suppression of RAN translation in vitro

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2.2.1 Anti-oxidant effects Oxidative stress in the nigrostriatal pathway is a defining pathological hallmark of PD, and BL, as an endogenous antioxidant, can exert neuroprotective effects by attenuating DA neuron degeneration ( Mitochondrial dysfunction plays a pivotal role in PD-associated oxidative pathology through four interconnected mechanisms: progressive depletion of nigral glutathione (GSH
