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The protein:ligand complex was crystallized after 3 days of incubation at 20 C in 20 mM zinc chloride and 20% (w/v) PEG 3,350 by the hanging-drop vapor diffusion method (2 L protein-ligand complex:2 L crystallization solution)

Presuming that the putative high-folatelow-vitamin B-12 interaction on serum holoTC and the metabolic markers of vitamin B-12 status is due to excess folic acid, an important consideration is at what level of exposure might these effects become metabolically and clinically relevant

Angew Chem Int Ed Engl

Based on pill count, the decedent was believed not to have ingested an excessive amount of quetiapine to attain the observed supratherapeutic blood concentration

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