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Clinical and preclinical investigations have shown that inhaled nanoparticlebased therapeutics can achieve effective treatment outcomes with reduced drug doses or dosing frequency, and through combination strategies that codeliver multiple therapeutic agents with different targets

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Furthermore, in vitro experiments using cultured human retinal Muller glia and retinal pigment epithelial (RPE) cells showed that GSNO treatment reduced SA-induced inflammatory mediators and cell death

The inhibition of Nrf2 could block these protective effects of MitoQ 49

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