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Every effort was made to minimize the number of animals used and their suffering

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Dynamic DNA methylation changes have also been reported to impact porcine immune responses by regulating the expression of immune-related genes

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The intestinal microbiota enhances the toxicity by hydrolysing to form T-23glucoside causing the autophagy, hypoxia-inducible factors and exomes mediated T-2 toxin induced immunotoxicity

Likewise, there are inhibited the mRNA of inflammatory mediators ( iNOS , IL-6, IFN, and TNF-), increased expression of HSP 70 and 90, and antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi [5]