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This process involves the cytosolic enzyme serine hydroxymethyltransferase (SHMT1), which catalyzes the conversion of serine to glycine and transfers a one-carbon unit to THF to form 5,10-methylenetetrahydrofolate

It has been shown that FGF-2 proteins including the variants are lacking secretory signal peptide (41)

PMID: 40930321 Cell Signal Deficiency of FUN14 domain-containing 1 enhances the migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis through mitochondrial dysregulation

The cell regenerates G-SH in a reaction catalyzed by glutathione reductase, using NADPH as a source of reducing equivalents

Zhang WJ, Bird KE, McMillen TS, LeBoeuf RC, Hagen TM, Frei B