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The De Novo Pathway begins with the condensation of L-serine and a fatty-acyl CoA such as palmitoyl-CoA, myristoyl CoA, or stearoyl CoA at the endoplasmic reticulum catalyzed by the enzyme serine palmitoyltransferase (SPT) to form 3-ketosphinganine, which is then reduced to dihydrosphingosine by the NADH-dependent 3-ketosphinganine reductase (KDSR)

Cancer Res (Suppl)

doi: 10.1161/01.RES.86.2.125 [DOI] [PubMed] [Google Scholar] 49

J Cosmet Dermatol 21(11):53705385 Sarkar D, Das S, Kalita P, Pathak BJ, Judder MI, Datta K, Alam F (2023) Traditional Indian medicinal plants for the treatment of psoriasis: a review of active constituents and their pharmacological effects

In addition, BPC 157 exhibits a particular effect on muscle healing in general terms as well
