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In this form, glutathione can be transported more effectively across the cell membrane

Therefore, to understand the effects of amino acid metabolism on macrophage function, it is necessary to analyze the node-specific roles of different amino acids within a unified metabolic network framework

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In addition, using a modified in vitro culturing system, which combines hypoxia and physiological levels of glutamine, we found that patient-derived melanoma cells exhibit differential metabolism in normoxia compared to hypoxia, indicating that hypoxia in the tumour microenvironment greatly affects glutamine metabolism