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The GSH adducts formed in such reactions are in most cases less toxic than the unconjugated substrates, and the GSH conjugates can in many cases be efficiently removed from the cells by multidrug resistance protein (Mrp) mediated export (Figure 2) (Dringen et al
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doi: 10.1016/j.kint.2022.01.013 131 GazittTEviatarTShearJMeidanRFurerVFeldJet al
Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: Design, synthesis, biological investigations, and in silico insights
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