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Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity

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Caregivers should encourage medical testing when vitamin B12 deficiency symptoms persist, worsen, or interfere with daily life

However, recent simulation studies demonstrate that either dosing method results in a similar degree of PK and PD variability suggesting that normalization of dose by body weight is an unnecessary step.36, 37, 38 Regardless of the option taken, the strategy should provide reduced interpatient variability to optimize therapeutic effect coupled with convenience, compliance, and costeffectiveness