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Later, this new coronavirus, SARS-CoV-2, was identified as a single-stranded RNA virus belonging to group 2B of the -coronavirus family (Hui et al
J Rhuematol 20:18451849 [PubMed] [Google Scholar] Kamalakkannan N, Prince PSM (2006) Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues
But on the other hand, NADPH supports ROS production via NOX2 and thereby, increased PPP and NADPH contribute to triggering ROS-dependent pro-inflammatory signaling cascades such as NF-B and MAPK (Koelwyn et al., 2018
Intriguingly, glutathione was found to be specifically concentrated in the basal bodies of smt15-1 and GSH2 overexpressors cells at the S/M phase
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Together, these two mechanisms seem to work jointly to enhance ROS levels and lead to cell death in cisplatin-resistant lung cancer cells
