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doi: 10.3389/fpls.2013.00477 Received 20 September 2013 Accepted 04 November 2013 Published 25 November 2013 Volume 4 - 2013 Edited by Jean-Philippe Reichheld, CNRS, France Reviewed by Christine H

Early-stage pathophysiological events associated with BBB breakdown after an ischemic stroke include the stimulation of sodium transporters (such as Na-K-Cl cotransporters, Na-H exchangers, etc.), which results in edema, and oxidative stress involving reactive oxygen species [72]

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