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In addition to the catalytic function of PCBD1, the protein serves as a transcriptional co-activator for two transcription factors of the hepatocyte nuclear factor-1 family, HNF-1 (encoded by the HNF1A gene) and HNF-1 (encoded by the HNF1B gene)

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Taken together, the in-vivo E-peptide literature partially rehabilitates the idea that the E-domain does something, while simultaneously demolishing the simplistic version of the story: the effects are context-dependent, age-dependent, only partly receptor-independent, and not unambiguously beneficial even in mice

1,2 Understanding the intricacies of zinc metabolism at the cellular level, including encompassing the absorption, intracellular trafficking, utilization, storage, and expulsion of zinc, can shed light on the various effects of zinc in cell physiology and pathology

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