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The SIRT/FOXO signaling pathway has been shown to prevent oxidative stress in cerebral ischemia-reperfusion

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Flanagan EW, Most J, Mey JT, Redman LM (2020) Calorie Restriction and Aging in Humans Annual Rev Nutrit 40:105133

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Our results argue that inversely coupled low thiols/high ROS in mitochondria may trigger UPR, the elevated stress resistance, and increased lifespan (Fig