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The severity and speed of onset of radiation-induced GHD are dose-dependent, and the incidence also increases over time elapsed after irradiation

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Moderate levels are found in the periaqueductal gray matter and raphe nuclei, and low concentrations are seen in the hypothalamus, preoptic area, and globus pallidus (Quirion et al., The distribution of KOR demonstrates some of the most striking species differences among the OR types

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and BPC-157 supports local vascularity and inflammation control