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Complementary evidence comes from Wang et al., who used cadmium-induced testicular toxicity model in male rats and showed that quercetin mitigated oxidative damage in the testes by evaluating SOD, GPx, CAT and GSH, lowering MDA levels, and reducing cadmium accumulation

Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

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The image of GPX4 KO A375 cells treated with indicated compounds 5 days after withdrawal of Lip1

Both approaches enhance wound healing through different mechanisms