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Efforts have been made to target serine metabolism, with a specific focus on phosphoglycerate dehydrogenase (PHGDH), a rate-limiting enzyme in the serine de novo synthesis pathway 38,151,152,153

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But according to the metal cofactors at their active sites, SODs can also be divided into four different types: Nickel SOD (Ni-SOD), manganese SOD (Mn-SOD), iron SOD (Fe-SOD) and copperZinc SOD (Cu,Zn-SOD) [14]

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