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Recent studies have shown that at least one mechanism of colchicines action is by acting to prevent a cascade of reactions that lead to the production of interleukin 1-beta, which is an inflammatory protein (cytokine), which is important in gouty inflammation.8 When used as one or two tablets a day (0.6mg each), most people tolerate this medication well, and this dose can help prevent gout attacks

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[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Du K., Ramachandran A., McGill M.R., Mansouri A., Asselah T., Farhood A., Woolbright B.L., Ding W.X., Jaeschke H

The fate of cyclamate in man and other species