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Specifically, p66Shc can generate ROS through the oxidation of cytochrome c by utilizing the reducing equivalents of the mitochondrial ETC, playing a crucial role in carcinogenesis and aging [44]
Also, when pHi increases, H + diffusion increases [273], possibly enhancing pH reversal for survival and dedifferentiation as single, migrating cells
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linked GADD45 overexpression to promoter hypomethylation, affecting cisplatin sensitivity through the disruption of apoptotic pathways [108]
Subsequently, straight scratches were made with a p200 pipette tip across the 60-mm culture dish, simulating a wound
