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CBD can reduce fibrosis by downregulating intracellular ROS generation and lipid peroxidation [73,142], inhibiting profibrotic signaling often associated with IL-6 [143] and IL-1 production [144], and favoring the transition of CD133+ progenitor cells into myofibroblasts [145]

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Research guide: BPC-157 Research Guide

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Nat Rev Cancer 2013;13:714-26

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Variations in genes related to maintaining mitochondrial balance are strongly linked to the susceptibility to CD and its clinical progression

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The C5ORF33 gene makes mitochondrial NAD kinase (MNADK or NADK2) that creates NADP+ in mitochondria

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Marsicano G, Moosman B, Herman H, Lutz B, Behl C

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