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The balance between these two polarized macrophages is important because previous studies demonstrated that TAMs are predominantly M2-like macrophages and they are associated with cancer progression 16,17,18

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In a nutritional model of steatosis in rats, Grattigliano et al

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Then these cells were stimulated to M1-like or M2-like polarization and treated via different concentrations of SP (cells/mL, 1.2 10 6 , 2.5 10 6 , 5 10 6 , 1 10 7 ) for 24 h