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Abstract Homeostasis is the regulatory mechanism for the expression of all genes, the function of all metabolic pathways, the utilization of any essential trace element (TEs), while its disruptions lead to many pathological states

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Utilizing probiotic microbiota and their exopolysaccharides to address heavy metal toxicity offers a novel method for improving human health through modulation of the gut microbiome

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This review provides a comprehensive overview of bacterial fructan-metabolizing enzymes, integrating structural, biochemical, and ecological perspectives to establish a foundation for applying fructan-modifying enzymes to prebiotic production, food texturization, microbiome modulation, and emerging oral enzyme therapeutics.

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