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This is the same biological principle behind why tolerance develops with many medications

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After an equilibration period of 1040 min, AT-1002 (5 mg/ml) was applied to the apical bath by replacing 400 l of the bath medium with 400 l of medium containing the AT-1002 component

Tap water or bottled drinking water contains minerals, chlorine, and potentially bacteria that can damage peptides and cause contamination

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